Association of abnormal lipid metabolism with INSIG2 gene variant in overweight and obese children

VernacularTitle:超重肥胖儿童的脂代谢异常与INSIG2基因的关联研究
Author: Hai-Jun WANG ¹ ; Heng ZHANG ; Ji ZHANG ; Yan WANG ; Jun MA
Author Information

1. 北京大学
Keywords: Obesity; Children; INSIG2 gene
From: Chinese Journal of Epidemiology 2010;31(6):650-654
CountryChina
Language:Chinese
Abstract: Objective To study the relationship between insulin induced gene 2 (INSIG2) variant and obesity or lipid metabolism in Chinese children and adolescents. Methods A total number of 2030 school students at the age from 7 to 18 years were selected in Beijing. Physical indicators, serum lipids and the rs13428113 polymorphism in INSIG2 gene were examined for all the subjects. Results The overall mutation rate of the rs13428113 polymorphism (T>C) was 49.3%.The differences of genotype and allele frequencies were not statistically significant among normal-weight, overweight and obesity groups (P>0.05). Among the overweight students, those with CC genotype had higher body mass index, waist-hip ratio, bronchial triceps skin-fold, and anterior superior lilac spine skin-fold than TT/TC carriers. Among the obese group, those with CC genotype had higher total cholesterol level than TT/TC careers (P<0.05). Conclusion The rs13428113 polymorphism in INSIG2 gene was associated with abnormal lipid metabolism in overweight and obese children, which increasing the degree of obesity and abnormal serum lipids.