Survival analysis on 3103 HIV/AIDS patients receiving antiretroviral treatment in Dehong prefecture, Yunnan province
10.3760/cma.j.issn.0254-6450.2010.11.003
- VernacularTitle:云南省德宏州3103例艾滋病患者抗病毒治疗后生存分析
- Author:
Shi-Tang YAO
1
;
Song DUAN
;
Li-Fen XIANG
;
Run-Hua YE
;
Yue-Cheng YANG
;
Yan-Ling LI
;
Ji-Bao WANG
;
Jin YANG
;
Yin-Di ZHANG
;
Hai-Qin YANG
;
Yun SHI
;
Ru-Juan LI
;
Zhi-Jian ZHAI
;
Yu-Sheng DING
;
Wei-Hua YANG
;
Ying-Ying DING
;
Na HE
Author Information
1. 云南省德宏傣族景颇族白治州疾病预防控制中心
- Keywords:
HIV/AIDS patient;
Antiretroviral treatment;
Survival analysis
- From:
Chinese Journal of Epidemiology
2010;31(11):1215-1218
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the survival rate of HIV/AIDS patients after receiving free antiretroviral treatment in Dehong prefecture, Yunnan province. Methods A retrospective cohort analysis was conducted on all the HIV/AIDS patients aged over 16 years who had started antiretroviral treatment during January 2007 throughout December 2009 in Dehong prefecture.Results A total of 3103 HIV/AIDS patients had received antiretroviral treatment during the study period. Among them, the mean age was (36.0 ± 9.9) years and 62.4% were males. 66.2% of them were infected with HIV through heterosexual transmission, and the mean treatment follow-up time was 21.7 months. Most patients well complied with the treatment, i.e., the average times of not taking the medicine were less than 5 per month. The cumulative survival rate of antiretroviral treatment after 1, 2, 3, 4, and 5 years were 0.95, 0.94, 0.93, 0.92, and 0.92, respectively. Data from the Cox proportional hazard regression model analysis indicated that, after adjustment for age, gender, and marital status, the baseline CD4+T cell counts and transmission route could significantly predicate the rates of survival. Those who were with baseline CD4+T cell counts as 200-350/mm3 were less likely to die of AIDS than those with CD4+T cell counts ＜200/mm3 (Hazard Ratio or HR=0.16, 95%CI:0.09-0.28), and HIV-infected through mother-to-child transmission or routes other than heterosexual transmission were less likely to die of AIDS than through injecting drug use (HR=0.35, 95% CI:0.13-1.00). Conclusion Free antiretroviral treatment had significantly improved the survival of HIV/AIDS patients. Earlier initiation of antiretroviral treatment was likely to have achieved better survival effects.
