Relationship between genetic polymorphism of ERCC1 and susceptibility to liver cancer
10.3760/cma.j.issn.0254-6450.2010.11.020
- VernacularTitle:ERCC1基因多态性与肝癌易感性研究
- Author:
Zhi-Jian HU
1
;
Jin-Fa XUE
;
Xiao-Yang ZHANG
;
Xi-Shun SHI
;
Hong ZHOU
Author Information
1. 福建医科大学
- Keywords:
Liver cancer;
ERCC1;
Case-control study;
Gene polymorphism
- From:
Chinese Journal of Epidemiology
2010;31(11):1288-1291
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between genetic polymorphisms of ERCCl-C8092A and susceptibility to liver cancer, as well as the gene-environmental interaction on the etiology of liver cancer in Fuzhou. Methods A case-control study was conducted to collect the information on environmental exposure while genetic polymorphism of ERCC1 was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. General relative risk regression models were further applied to fit the interaction between genetic polymorphisms of ERCC1-C8092A and the environmental factors of liver cancer. Results ERCC1-C8092A variant genotypes were associated with significant increasing risk of liver cancer adjusted odds ratio (OR= 3.789,95%CI:2.792-5.142 ), compared to the wild-type homozygote. Data from the analysis of interaction showed that genetic polymorphism of ERCC1-8092A appeared superadditive interaction with drinking pond-ditch or with hepatitis B, and super-multiplicative interaction with eating moldy food. Conclusion The point mutation in ERCC1-8092A was possibly susceptible to liver cancer, and related synergistically with other risk factors in hepatocelluar carcinogenesis in Fuzhou.
