Evaluation on the accuracy of high-frequency ultrasound being used in the breast cancer screening program in women from Asian countries: a systematic review
10.3760/cma.j.issn.0254-6450.2010.11.022
- VernacularTitle:高频超声在亚洲女性中筛查乳腺癌准确性的系统评价
- Author:
Yuan HUANG
1
;
Yi PANG
;
Qiong WANG
;
Jia-Yuan LI
Author Information
1. 四川大学
- Keywords:
Breast cancer;
Screening;
High-frequency ultrasound;
Asian women;
Systematic review
- From:Chinese Journal of Epidemiology
2010;31(11):1296-1299
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the accuracy and value of high-frequency ultrasound for breast cancer screening in Asian women. Methods Published studies on high-frequency ultrasound for screening breast cancer in Asian women were systemically searched and assessed by the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) tool. Meta-DiSc 1.4 software was used for extracting data, calculating the summary sensitivity and specificity, and drawing the Summary Receiver Operating Characteristic (SROC) curve. Furthermore, the proportion of screening of diagnosis on early breast cancer (TNM stage 0, Ⅰ and Ⅱ ) by high-frequency ultrasound was calculated. Results Seven screening studies including 22 244 women were selected for Metaanalysis. According to the QUADAS items, 5 studies were classified as A degree and 2 studies were evaluated as B degree. For study in the heterogeneous of these 7 studies (Q=38.97, P＜0.0001 ),Random Effects Model (REM) was selected. The combined sensitivity (95%CI) and specificity (95%CI) were 0.785 (0.726-0.837) and 0.975 (0.973-0.977) respectively. The Area Under the Curve (AUC) of SROC was 0.9800. Among the follow-up studies of following period over one year, 96.9%of the diagnosed patients with breast cancer were at clinical stage Ⅱ or prior to it. Conclusion Because of its high accuracy, high- frequency ultrasound could be recommended for screening breast cancer in Asian women.
