Analysis on the decline of hepatitis C virus RNA in the blood using a mathematical model.
- Author:
Zu-Jiang YU
1
;
Quan-Cheng KAN
;
Yun HE
;
He-Qing JIANG
;
Hong-Xia LIANG
;
Tai-Sheng LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Half-Life; Hepacivirus; Hepatitis C, Chronic; blood; virology; Humans; Models, Theoretical; Nonlinear Dynamics; RNA, Viral; blood; Viral Load; Virus Replication
- From: Chinese Journal of Hepatology 2007;15(12):886-888
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a mathematical model of hepatitis C virus (HCV) replication and develop a working theory for antiviral therapy in order to understand the dynamics of HCV replication.
METHODSPeripheral blood cells of 4 hepatitis C patients were cultured. Quantities of the HCV were detected every 15 min by real-time PCR. The data were analyzed using SPSS software. A mathematical functional relationship between HCV RNA and the time lapse was established.
RESULTSThe quantity of HCV RNA declined and it fell into a mathematical model: Y=3E+0.8e(-0.5467x) (r=0.9547). The estimated virion half-life was 45 min on the average.
CONCLUSIONSThe decline of HCV RNA in the blood is not of a linear trend and the HCV RNA lasts a longer time although the speed of the decline is faster than that in vivo.
