Genetic polymorphism of dendritic cell-specific ICAM-3 grabbing nonintegrin and DC-SIGNR's exon 4 in Chinese hepatitis C patients.
- Author:
Min WANG
1
;
Hui WANG
;
Xiao-Ling JIANG
;
Jian LU
;
Yu-Lin ZHAN
;
Hong-Xing HAN
;
Xiao-Hua LE
;
Bo-Ping ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Asian Continental Ancestry Group; genetics; Blood Donors; Case-Control Studies; Cell Adhesion Molecules; genetics; Child; Exons; Female; Genetic Predisposition to Disease; Genotype; Hepatitis C, Chronic; ethnology; genetics; Humans; Lectins, C-Type; genetics; Male; Middle Aged; Polymorphism, Genetic; Receptors, Cell Surface; genetics; Young Adult
- From: Chinese Journal of Hepatology 2007;15(12):889-892
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study into the genetic polymorphism of DC-SIGN and DC-SIGNR's exon 4 in Chinese hepatitis C patients and its relationship with HCV infection susceptibility.
METHODSPatients with hepatitis C (n=300, group A) and healthy subjects (n=520, group B) were genotyped and analysed for the repeat sequence of polymorphism of DC-SIGN and DC-SIGNR's exon 4 using PCR and DNA sequencing.
RESULTSThe distribution of genotypes and alleles in DC-SIGN's exon 4 in the two groups did not differ significantly (P > 0.05). The difference of allele frequency in DC-SIGNR's exon 4 between the two groups was also not significant (P > 0.05). However, 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C was significantly higher than that in the healthy subjects (P < 0.05).
CONCLUSIONThere is no significant correlation between the genetic polymorphism of DC-SIGN's exon 4 and HCV infection susceptibility. 9/5 genotype distribution frequency of DC-SIGNR's exon 4 in patients with hepatitis C is significantly higher and may be associated with HCV infection susceptibility.
