Piggy-back liver transplantation in treating acute liver failure patients: a report of 15 cases.
- Author:
Qi-fa YE
1
;
Wan-ping CHEN
;
Ying-zi MING
;
Ke LI
;
Zhu-hai REN
;
Xing-guo SHE
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Female; Humans; Liver Failure, Acute; mortality; surgery; Liver Transplantation; methods; mortality; Male; Middle Aged; Retrospective Studies; Survival Rate; Young Adult
- From: Chinese Journal of Hepatology 2008;16(1):49-52
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical significance of piggy-back liver transplantation in treating acute liver failure (ALF).
METHODSFifteen ALF patients (13 caused by HBV and 2 with acute Wilson disease) had piggy-back liver transplantations (PBLT) in our hospital from Sept 1999 to Feb 2006. The outcomes of these patients were retrospectively analyzed.
RESULTSOne year survival rate of the 15 patients was 87% (13/15). Excellent outcome was achieved in the 2 acute Wilson disease cases: their corneal Kayser-Fleischer rings disappeared and serum ceruloplasmin levels returned to normal. Among the 15 cases, one died of severe pulmonary infection and another died of multiple organ system failure on the 6th and 11th postoperative days. HBsAg positivity was observed in 13 cases before liver transplantation. Eleven patients survived and later received anti-HBV treatment recommended by the American Association for the Study of Liver Diseases. Their HBsAg became negative.
CONCLUSIONLiver transplantation is an effective therapy for ALF and can improve survival rate significantly.
