Survival analysis for laryngeal carcinoma patients with no surgery, radiotherapy or chemotherapy
10.3760/cma.j.issn.1673-0860.2011.02.008
- VernacularTitle:未行喉切除术及放化疗治疗的喉癌患者生存分析
- Author:
Qiong YU
1
;
Guo-Hua HU
;
Xue-Yuan ZHANG
;
Chang-You JI
;
Hua YANG
;
Ming-Hua GAO
;
Su-Ling HONG
Author Information
1. 重庆市长寿区人民医院
- Keywords:
Laryngeal neoplasms;
Factor analysis,statistical;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(2):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the survival rate and prognostic factors of laryngeal carcinoma patients with no surgery,radiotherapy or chemotherapy.Methods One hundred and sixty-seven laryngeal carcinoma cases with no surgery,radiotherapy or chemotherapy were analyzed restrospectively.Survival rates were calculated by Kaplan-Meier product-limit method.With univariate analysis,comparisons among/between groups were performed using Log-rank test.Multivariate analysis was carried out using Cox proportional hazard model.Results Overall survival time was (16.0 ± 1.4) months (-x ± s),overall 1-and 2-year survival rates were 56.4％ and 26.5％,respectively.No patient survived over 5 years in these cases who had been diagnosed more than 5 years (except for those who lost).Univariate analysis showed that primary site,pathological grade,T-stage,N-stage and clinical stage were significant prognostic factors for the survival of the patients (P ＜ 0.05＝.The survival rates of laryngeal carcinoma whether with tracheotomy were no statistically significant (P＞0.05).Multivariate analysis showed survival rates statistically correlated with T stage and N stage (hazard ratio were 1.812 and 1.557,P ＜ 0.05).Conclusions The development of laryngeal carcinoma course was faster,without treatment to the tumor itself,even if palliative surgical such as tracheostomy would not improve the survival rate.In laryngeal carcinoma patients with no surgery,radiotherapy or chemotherapy,the factors affecting the survival rates include primary site,pathological grade,T-stage,N-stage and clinical stage,and of them,T-stage and Nstage are the independent prognostic factors.
