Clinical efficacy and immunological changes in children with allergic rhinitis receiving specific immunotherapy with Dermatophagoides pteronyssinus
10.3760/cma.j.issn.1673-0860.2011.01.016
- VernacularTitle:儿童变应性鼻炎免疫治疗的临床疗效及免疫学机制研究
- Author:
Cheng-Shuo WANG
1
;
Wei ZHANG
;
Xiang-Dong WANG
;
Lin XI
;
Yu-Hui OUYANG
;
Yan ZHAO
;
Yang WANG
;
Luo ZHANG
Author Information
1. 首都医科大学附属北京同仁医院
- Keywords:
Rhinitis,allergic,perennial;
Immunothcrapy;
Dermatophagoides farinae
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2011;46(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and immunological changes of children receiving subcutaneous immunotherapy with Dermatophagoides pteronyssinus. Methods Sixty-four children with allergic rhinitis to Dermawphagoides pteronyssinus (Der p) were randomly allocated to receive either specificimmunotherapy (n = 32) or medical treatment (n = 32 ). Symptom and medication scores were assessed toevaluate the clinical efficacy in the baseline and after one year treatment. Total IgE, Der p-specific IgE, and specific IgG4 were measured. Results Immunotherapy reduced the symptom ( the scores reduced from 10[9;11] to4[3;6]) and medication score (the scores reduced from 0.76[0.61; 0.90] to 0.35[0.30;0. 43] ) in children with arlergic rhinitis significantly ( Z value were - 4.80 and - 4.74, respectively, each P＜0.01 ). There was a significant difference in symptom and medication scores between both groups after one year treatment ( U value were 155. 00 and 139.50, respectively, each P ＜ 0.01 ). There were no differences in levels of serum total IgE, specific IgE before and after one year treatment, but the level of serum specific IgG4 increased significantly after one year treatment. Conclusions Immunotherapy with standardized extract is efficacious to treat children sensitive to Der p, allergen-specific IgG4 is significant as immunological marker to predict efficacy of immunotherapy.
