Expression of Piwil2 and its relationship with tumor invasion and metastasis in papillary thyroid carcinoma

VernacularTitle:PiWil2在甲状腺乳头状癌中的表达及其与侵袭转移的关系
Author: De-Tao YIN ¹ ; Hong-Qiang LI ; Yong-Fei WANG ; Sheng-Li CAO ; Yu-Bing ZHOU ; Li-Yun ZHENG ; Jin-Hua JIANG ; Qing-Duan WANG
Author Information

1. 郑州大学附属第一医院
Keywords: Thyroid neoplasms; Carcinoma,papillary; In situ hybridization; Proteins
From: Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2011;46(3):237-239
CountryChina
Language:Chinese
Abstract: Objective To study the expressions of Piwil2 protein and mRNA in papillary thyroid carcinoma(PTC) and the relationship between Piwil2 and the invasion and metastasis of PTC. Methods Immunohistochemistry and in situ hybridization were used to detect the expression of Piwil2 protein and mRNA in 60 cases of PTC with the matched adjacent non-cancerous epithelium (NCE). Results The positive rates of Piwil2 protein expression in PTC and NCE were 88.3% (53/60) and 10.0% (6/60)respectively, with significant difference ( x2 = 73. 654,P ＜ 0.01 ). The positive rates of Piwil2 mRNA expression in PTC and NCE were 85.0% (51/60) and 6. 7% (4/60) respectively, also with significant difference (x2 =74. 148 ,P ＜0.01 ). Up-regulated expressions of Piwil2 protein and mRNA were related to the invasion and metastasis of PTC (P ＜ 0.05 ). Conclusion Piwil2 may play a role in the invasion and metastasis of PTC.