Expression and diagnostic application of C4.4A protein in squamous cell carcinoma and adenocarcinoma.
- Author:
Wei WANG
1
;
Yan-qing DING
;
Zu-guo LI
;
Hui-xia HAN
;
Lei YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; diagnosis; metabolism; Biomarkers, Tumor; metabolism; Carcinoma, Squamous Cell; diagnosis; metabolism; Cell Adhesion Molecules; metabolism; Colorectal Neoplasms; diagnosis; metabolism; Diagnosis, Differential; Esophageal Neoplasms; diagnosis; metabolism; Female; GPI-Linked Proteins; Humans; Immunohistochemistry; Lung Neoplasms; diagnosis; metabolism; Male; Stomach Neoplasms; diagnosis; metabolism; Uterine Cervical Neoplasms; diagnosis; metabolism
- From:Chinese Journal of Pathology 2006;35(5):277-280
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the diagnostic utility of C4.4A gene expression in discriminating a squamous cell carcinoma (SCC) from an adenocarcinoma by immunohistochemistry.
METHODSImmunohistochemical staining was performed to detect the expression of C4.4A protein in 157 cases of SCC and 177 cases of adenocarcinoma of various organs.
RESULTSOverall, 141 of 157 cases of SCC strongly expressed C4.4A protein. In contrast, only 8 of 177 adenocarcinomas showed partial or scattered cell expression of C4.4A protein. The statistic difference between the two groups was highly significant (chi(2) = 244.93, P = 0.000), and also when the tumors were stratified according to the degree of differentiation (P = 0.000).
CONCLUSIONC4.4A protein expression may serve as a valuable tumor marker in discriminating a squamous cell carcinoma from an adenocarcinoma, and therefore, may greatly facilitate the differential diagnosis of an epithelial malignancy.
