Clinicopathologic manifestation of amiodarone-induced lung injury.
- Author:
Ju-hong SHI
1
;
Hong-rui LIU
;
Yuan-jue ZHU
;
Wen-bing XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Amiodarone; adverse effects; Anti-Arrhythmia Agents; adverse effects; Biopsy; Follow-Up Studies; Glucocorticoids; therapeutic use; Humans; Lung; drug effects; pathology; radiation effects; Lung Diseases, Interstitial; chemically induced; drug therapy; pathology; Lung Injury; chemically induced; drug therapy; pathology; Male; Middle Aged; Prednisone; therapeutic use; Pulmonary Alveoli; drug effects; pathology; Retrospective Studies; Tomography, X-Ray Computed
- From: Chinese Journal of Pathology 2006;35(7):394-397
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical, pathologic and radiologic features of amiodarone-induced lung injury.
METHODSThe clinical, pathologic and radiologic features, including treatment and follow-up information of three cases diagnosed as amiodarone-induced lung injury from October 2004 to October 2005 in the Peking Union Medical College Hospital were reviewed.
RESULTSAll the patients were males, with age ranging from 35 to 64 years. The duration of symptoms varied from 20 days to 3 years. All presented with cough. Worsening dyspnea and inspiratory crackles were noted in two patients. Computerized tomography showed bilateral patchy infiltration, ground-glass appearance and accentuation of bronchovascular markings. The most common pathologic manifestations included cellular interstitial pneumonia associated with intra-alveolar collections of macrophages and type II pneumocyte hyperplasia. Some of the macrophages contained finely vacuolated cytoplasm. An organizing pneumonia pattern was seen in one patient.
CONCLUSIONSAmiodarone-induced lung injury has characteristic pathologic features which may provide clues to diagnosis. Correlation with clinical and radiologic findings is also important.
