Brain metastases of melanoma--mechanisms of attack on their defence system by engineered stem cells in the microenvironment.
- Author:
Borislav D DIMITROV
1
;
Penka A ATANASSOVA
;
Mariana I RACHKOVA
Author Information
1. BORDANI, Alzano Lombardo, Bergamo 24022, Italy. bdd11@yahoo.com
- Publication Type:Journal Article
- MeSH:
Brain Neoplasms;
immunology;
surgery;
Humans;
Immunity, Innate;
immunology;
Melanoma;
immunology;
secondary;
surgery;
Models, Immunological;
Stem Cell Transplantation;
methods
- From:
Journal of Zhejiang University. Science. B
2007;8(9):609-611
- CountryChina
- Language:English
-
Abstract:
This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.
