Lance-Adams syndrome: a report of two cases.
- Author:
Yan-xing ZHANG
1
;
Jian-ren LIU
;
Biao JIANG
;
Hui-qin LIU
;
Mei-ping DING
;
Shui-jiang SONG
;
Bao-rong ZHANG
;
Hong ZHANG
;
Bin XU
;
Huai-hong CHEN
;
Zhong-jin WANG
;
Jian-zheng HUANG
Author Information
1. Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Case Reports
- MeSH:
Cardiopulmonary Resuscitation;
adverse effects;
Cerebellar Ataxia;
diagnosis;
etiology;
Female;
Humans;
Hypoxia-Ischemia, Brain;
diagnosis;
etiology;
Middle Aged;
Myoclonus;
diagnosis;
etiology;
Syndrome
- From:
Journal of Zhejiang University. Science. B
2007;8(10):715-720
- CountryChina
- Language:English
-
Abstract:
Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS), is a rare complication of successful cardiopulmanry resuscitation often accompanied by action myoclonus and cerebellar ataxia. It is seen in patients who have undergone a cardiorespiratory arrest, regained consciousness afterwards, and then developed myoclonus days or weeks after the event. Worldwide, 122 cases have been reported in the literature so far, including 1 case of Chinese. Here we report 2 Chinese LAS patients with detailed neuroimagings. Cranial single photon emission computed tomography (SPECT) of patient 1, a 52-year-old woman, showed a mild hypoperfusion in her left temporal lobe, whereas patient 2, a 54-year-old woman, manifested a mild bilateral decrease of glucose metabolism in the frontal lobes and a mild to moderate decrease of the N-acetyl aspartate (NAA) peak in the bilateral hippocampi by cranial [(18)F]-fluorodeoxyglucose positron emission tomographic (PET) scan and cranial magnetic resonance spectroscopy (MRS), respectively. We also review the literature on the neuroimaging, pathogenesis, and treatment of LAS.
