BRCA1/2 associated hereditary breast cancer.

Author: Li-song TENG ¹ ; Yi ZHENG ; Hao-hao WANG
Author Information

1. Cancer Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China. lsteng@zju.edu.cn
Publication Type:Journal Article
MeSH: Apoptosis Regulatory Proteins; BRCA1 Protein; genetics; physiology; BRCA2 Protein; genetics; physiology; Breast Neoplasms; genetics; metabolism; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Genetic Diseases, Inborn; Genetic Predisposition to Disease; Humans; Mutation; Prognosis
From: Journal of Zhejiang University. Science. B 2008;9(2):85-89
CountryChina
Language:English
Abstract: Breast cancer is one of the leading causes of death in women today. Some of the patients are hereditary, with a large proportion characterized by mutation in BRCA1 and/or BRCA2 genes. In this review, we provide an overview of these two genes, focusing on their relationship with hereditary breast cancers. BRCA1/2 associated hereditary breast cancers have unique features that differ from the general breast cancers, including alterations in cellular molecules, pathological bases, biological behavior, and a different prevention strategy. But the outcome of BRCA1/2 associated hereditary breast cancers still remains controversial; further studies are needed to elucidate the nature of BRCA1/2 associated hereditary breast cancers.