Screening analysis of irregular antibodies from random donor population in Shaoguan area.
- Author:
Jian-Ying ZHU
1
;
Jiong-Cai LAN
;
Hong-Qing LUO
Author Information
1. Central Blood Bank of Shaoguan, Shaoguan 512026, China.
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Blood Donors;
China;
Erythrocytes;
immunology;
Female;
Humans;
Isoantibodies;
blood;
Male;
Mass Screening;
Middle Aged;
Rh-Hr Blood-Group System;
blood;
immunology;
Rho(D) Immune Globulin
- From:
Journal of Experimental Hematology
2007;15(3):630-631
- CountryChina
- Language:Chinese
-
Abstract:
The study was purposed to analyze the frequency and distribution of irregular antibodies in Shaoguan area. Screening 15 033 random donor antibodies in Shaoguan area by screening cells, polybrene and antiglobulin tests. The results indicated that the irregular antibodies were found in 42 samples. The frequency of irregular antibodies in female was higher than that in male (P < 0.001), and Rh blood group antibodies such as anti-D, anti-E, and anti-Ec C were common (47.6%). 2 samples of Le antibodies were failed to be found by polybrene test. 2 samples of irregular antibodies with titer 2 were undiscovered by screening test of 10 pooled samples. In conclusion, because of irregular antibodies resulting in hemolytic transfusion reaction, the investigation of frequency and distribution of irregular antibodies is very important for safe transfusion. Antibody screening must be done for female donors, and especially for massive plasma transfusion of patients with severe and dangerous illness and infants so as to ensure safety.
