Suppression of gene transcription by polyamide - review.
- Author:
Bin CHU
1
Author Information
1. Department of Hematology, Peking Univesity First Hospital, Beijing 100034, China. zhuping@bjmu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
Gene Silencing;
drug effects;
HIV;
genetics;
Humans;
Neoplasms;
genetics;
Nylons;
pharmacology;
Transcription, Genetic;
drug effects
- From:
Journal of Experimental Hematology
2007;15(3):675-678
- CountryChina
- Language:Chinese
-
Abstract:
Polyamide is a synthetic small molecule that recognizes predetermined sequences in the minor groove of DNA with affinities and specificities compared to those of DNA-binding proteins. Polyamide can suppress gene transcription by interfering with the attachment of natural transcription factors and DNA. The alkylating polyamides represent a novel approach for sequence-specific gene silencing, which might be applied to gene therapy. The research on suppression of gene transcription by polyamide was reviewed in this paper.
