Advance of study on Mer function.
- Author:
Lei FAN
1
;
Chang-Geng RUAN
Author Information
1. Jiangsu Institute of Hematology, The First Affiliated Hospital of Suzhou University, Suzhou 215006, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Fibrinolytic Agents;
Humans;
Intercellular Signaling Peptides and Proteins;
metabolism;
Proto-Oncogene Proteins;
genetics;
metabolism;
Receptor Protein-Tyrosine Kinases;
genetics;
metabolism;
Signal Transduction;
c-Mer Tyrosine Kinase
- From:
Journal of Experimental Hematology
2007;15(4):892-895
- CountryChina
- Language:Chinese
-
Abstract:
Mer is one member of Axl receptor tyrosine kinase family, and its ligand Gas6 can stimulate activity of Mer receptor tyrosine kinase after binding it, and then activate the downstream signal transduction pathway, Mer participates in cell inflammation, apoptosis, tumorigenesis, thrombosis and hemostasis. Rencet advances of study on Mer function were reviewed, and its potential prospects of antithrombosis and antitumor were discussed in this article.
