Expression of cyclooxygenase-2 in bone marrow cells of chronic leukemia and its significance.
- Author:
Zhen-Hua BAO
1
;
Guang-Lun LI
;
Jun-Hong YU
Author Information
1. Department of Hematology, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China.
- Publication Type:Journal Article
- MeSH:
Adult;
Aged;
Bone Marrow Cells;
enzymology;
Cyclooxygenase 2;
metabolism;
Gene Expression;
Humans;
L-Lactate Dehydrogenase;
metabolism;
Leukemia, Lymphocytic, Chronic, B-Cell;
enzymology;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
enzymology;
Middle Aged
- From:
Journal of Experimental Hematology
2007;15(5):923-926
- CountryChina
- Language:Chinese
-
Abstract:
The study was aimed to investigate the expression of COX-2 in bone marrow cells of chronic leukemia patients and its potential pathogenetic implications. Western blot was applied for detecting COX-2 expression levels in bone marrow cells of 67 chronic leukemia patients and beta-actin expression levels. Bone marrow aspirations from 14 healthy donors were used as negative controls. The results showed that the positive rates of COX-2 in chronic-phase group of chronic myeloid leukemia (CML-CP) and in group of chronic lymphocytic leukemia (CLL) were 76.32% (29/38) and 75.86% (22/29) respectively. Both CML-CP and CLL group showed a higher expression than control group (p = 0.0000, p = 0.0000 respectively). The expression of LDH in Cox-2 positive group was higher than that in Cox-2 negative group, and the difference between the two groups was statistically significant (p < 0.001). It is concluded that the expression of COX-2 protein can be detected in bone marrow cells of CML-CP and CLL and the expression level of LDH were higher in cells of CML-CP and CLL. The expression of COX-2 may be correlated with prognosis of CML-CP and CLL.
