Usefulness of Gadobenate Dimeglumine - Enhanced Hepatobiliary Phase MR Imaging on Predicting Histological Grade of Hepatocellular Carcinoma.
10.13104/jksmrm.2011.15.3.208
- Author:
Sung Ho PARK
1
;
Myeong Jin KIM
;
Jin Young CHOI
;
Joon Seok LIM
;
Ki Whang KIM
Author Information
1. Department of Radiology, Research Institute of Radiological Science, Institute of Gastroenterology, Yonsei University College of Medicine, Korea. kimnex@yuhs.ac
- Publication Type:Original Article
- Keywords:
Hepatocellular carcinoma;
Magnetic resonance imaging;
Gadobenate dimeglumine;
Histological grade;
Hepatobiliary phase
- MeSH:
Carcinoma, Hepatocellular;
Humans;
Liver;
Magnetic Resonance Imaging;
Meglumine;
Organometallic Compounds;
Retrospective Studies;
Signal-To-Noise Ratio
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2011;15(3):208-218
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To assess the usefulness of gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging for evaluation of histological characteristics of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: 57 HCCs histopathologically proved by surgery in 51 patients were retrospectively evaluated. All patients underwent gadobenate dimeglumine-enhanced MR imaging prior to surgery. The signal-to-noise ratio (SNR) of lesion and liver, and the liver-to-lesion contrast-to-noise ratio (CNR) for both pre- and postcontrast hepatobiliary phase were measured and contrast enhancement ratio (CER) of lesion and liver were calculated to correlate with three groups stratified by histological grades (Edmondson-Steiner classification) of the lesions. The differences between means of each group were statistically analyzed with one-way analysis of variance test. RESULTS: The liver-to-lesion CNRs of well-differentiated HCCs (n=9) on pre- (-0.8+/-13.2) and postcontrast hepatobiliary phase images (13.2+/-30.4) were significantly lower (p<0.05) compared to those of moderately (14.2+/-9.4 and 39.1+/-15.4 on pre- and postcontrast, respectively) (n=37) and poorly differentiated HCCs (18.6+/-11.3 and 39.3+/-27.9) (n=11), respectively. There were no significant difference for CERs between three histological tumor grades. CONCLUSION: Gadobenate dimeglumine-enhanced hepatobiliary phase MR imaging can help predict the histological grades of hepatocellular carcinomas preoperatively, especially differentiating well- from moderately and poorly differentiated HCCs.
