The effect of huanglian jiedu tang on Alzheimer's disease and its influence on cytokines.
- Author:
Qing FANG
1
;
Xiao-ping ZHAN
;
Jian-ling MO
;
Mei SUN
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; blood; psychology; Animals; Coptis; chemistry; Cytokines; blood; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Gardenia; chemistry; Interferon-gamma; blood; Interleukin-2; blood; Male; Memory; drug effects; Phellodendron; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley; Scutellaria; chemistry; Tumor Necrosis Factor-alpha; metabolism
- From: China Journal of Chinese Materia Medica 2004;29(6):575-578
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of huanglian jiedu tang on Alzheimer' s disease, and its influence on cytokines.
METHODAD rats models were made by A beta injection, and then water-maze tests were made to investigate the study and memory ability. TNF-alpha, INF-gamma and IL-2 were examined by ELISA. After treatment with huanglian jiedu tang, the rats were evaluated again.
RESULTAfter A beta injection, the study and memory ability of the rats was decreased. By the treatment with huanglian jiedu tang, it was improved (P < 0.01); TNF-alpha, INF-gamma and IL-2 levels of AD rats were higher than those in control group (P < 0.01); after treatment the levels came down (P < 0.01).
CONCLUSIONHuanglian jiedu tang can improve the study and memory ability of AD rats by changing their immune state.
