Studies on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs.
- Author:
Ai-hua LIANG
1
;
Xiao-shuang DING
;
Bao-yan LIU
Author Information
1. Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, 100700, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Aristolochiaceae;
chemistry;
Aristolochic Acids;
adverse effects;
isolation & purification;
toxicity;
Drugs, Chinese Herbal;
adverse effects;
isolation & purification;
toxicity;
Fibrosis;
Humans;
Kidney;
pathology;
Kidney Tubules;
pathology;
Nephritis, Interstitial;
chemically induced;
pathology;
Plants, Medicinal;
chemistry;
Renal Insufficiency;
chemically induced
- From:
China Journal of Chinese Materia Medica
2004;29(1):10-14
- CountryChina
- Language:Chinese
-
Abstract:
The article summarized the general situation of the study on the renal toxicity caused by aristolochic acids (AAs) and Chinese herbs containing AAs. The renal lesion induced by AAs and Chinese herbs containing AAs locates mainly in renal tubules, and glomeruluses have no obvious histological change. The short term administration of large doses causes acute renal epithelia denaturalization and tubular necrosis, but the long-term administration may result in chronically progressive interstitial fibrosis of the kidney. Renal failure may occur following both acute and chronic renal lesion. The renal function should be strictly monitored while one is using the Chinese herbs containing AAs, and the dosage and duration for the treatment must be limited to prevent renal toxicity.
