A Comparison Study on Human Brain Volume of White Matter, Gray Matter and Hippocampus Depending on Magnetic Resonance Imaging Conditions and Applied Brain Template.
10.13104/jksmrm.2011.15.3.242
- Author:
Won Beom JUNG
1
;
Doo Beom SON
;
Young Ju KIM
;
Young Hoon KIM
;
Choong Ki EUN
;
Chi Woong MUN
Author Information
1. Department of Biomedical Engineering and FIRST/UHRC, Inje University, Korea. mcw@inje.ac.kr
- Publication Type:Original Article
- Keywords:
Brain volumetry;
Magnetic resonance imaging (MRI);
Segmentation;
Brain template;
Hippocampus
- MeSH:
Aged;
Brain;
Hippocampus;
Humans;
Magnetic Resonance Imaging;
Magnetic Resonance Spectroscopy;
Magnetics;
Magnets;
Orientation
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2011;15(3):242-250
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to examine the volume differences of human brain 3-D MR images obtained by automatic segmentation methods depending on brain templates and image acquisition conditions, respectively. MATERIALS AND METHODS: 3D T1-weighted MR images oriented in coronal and sagittal plane were acquired from eight healthy subjects (29.5+/-5.66 years) using two identical 3T MR scanners at different sites. Caucasian brain template and Korean elderly brain template were applied for the same subject to segment brain structural region. Volumetric differences and variation of gray matter, white matter and hippocampus depending on scan orientations and brain template types were statistically evaluated. RESULTS: Volumetric measurements have some different results for the same subject images depending on scan orientation in identical MR scanners but not significantly. However, all segmented volumes relied upon brain templates were significantly different (p<0.05). Small variation of the volume in gray matter, white matter (coefficient of variation, CV< or =1%) and hippocampus (CV< or =3%) were obtained. Comparing the mean CV in all segmented regions, variation of scan orientation was not significantly different with inter scanner variation but variation relied upon brain templates were significantly different (p<0.001). CONCLUSION: Authors found that brain template regarding the specific properties of the subjects is required to reduce the errors of brain volumetry.
