Freeze-drying of silymarin-loaded solid lipid nanoparticles (SM-SLN).
- Author:
Jun HE
1
;
Jian-fang FENG
;
Le-le ZHANG
;
Wei-gen LU
;
Shi-xiang HOU
Author Information
- Publication Type:Journal Article
- MeSH: Drug Carriers; chemistry; Freeze Drying; methods; Glucose; chemistry; Lactose; chemistry; Lipids; chemistry; Milk Thistle; chemistry; Nanotechnology; Particle Size; Plants, Medicinal; chemistry; Silymarin; administration & dosage; chemistry; isolation & purification; Technology, Pharmaceutical; methods
- From: China Journal of Chinese Materia Medica 2005;30(2):110-112
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate lyophilization of SM-SLN.
METHODThe parameters of lyophilization process was optimized. In addition, the protective effect of various types and concentrations of cryoprotectants were tested by shape, colour and disparity.
RESULTThe mixture of 2% lactose and 2% glucose could better prevent nanoparticles from aggregating, the optimal lyophilization process was followed: precooled at -45 degrees C for 10 hr; primary drying at -25 degrees C for 5 hr; secondary drying at 10 degrees C for 3 hr; finally drying at 30 degrees C for 6 hr.
CONCLUSIONChanges in particle size distribution during lyophilization could be minimized by optimizing the parameters of the lyophilization process and adding supporting agent.
