Cyclophilin A: A Mediator of Cardiovascular Pathology.
10.5646/jksh.2011.17.4.133
- Author:
Nwe Nwe SOE
1
;
Bradford C BERK
Author Information
1. Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. bradford_berk@urmc.rochester.edu
- Publication Type:Review
- Keywords:
Cyclophilin A;
Oxidative stress;
Cardiovascular diseases
- MeSH:
Aortic Aneurysm, Abdominal;
Arthritis, Rheumatoid;
Atherosclerosis;
Autoimmune Diseases;
Cardiomegaly;
Cardiovascular Diseases;
Cyclophilin A;
Cyclophilins;
Myocardial Reperfusion Injury;
Oxidative Stress;
Protein Transport;
Proteins;
Quaternary Ammonium Compounds;
Signal Transduction
- From:Journal of the Korean Society of Hypertension
2011;17(4):133-147
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cyclophilin A (CyPA) is a 17 kDa, ubiquitously expressed multifunctional protein that possesses peptidylprolyl cis-trans isomerase activity and scaffold function. Its expression is increased in inflammatory conditions including rheumatoid arthritis, autoimmune disease and cancer. Intracellular CyPA regulates protein trafficking, signal transduction, transcription regulation and the activity of certain other proteins. Secreted CyPA activates cardiovascular cells resulting in a variety of cardiovascular diseases; including vascular remodeling, abdominal aortic aneurysms formation, atherosclerosis, cardiac hypertrophy and myocardial ischemic reperfusion injury.
