Enhanced absorption of breviscapine photosomes in small intestine of rats.
- Author:
Xiao-qiao TANG
1
;
Xiang-liang YANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asteraceae; chemistry; Drug Carriers; Flavonoids; administration & dosage; isolation & purification; pharmacokinetics; Intestinal Absorption; Intestine, Small; metabolism; Male; Phospholipids; chemistry; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2005;30(3):222-225
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate whether the absorption of breviscapine can be enhanced by using breviscapine photosomes.
METHODTesting the uptake and intestinal permeability of breviscapine powder and breviscapine photosomes by using intestine perfusion technique and reverted gut sac method.
RESULTThe uptake and permeability coefficient of breviscapine were increased in photosomes. The absorption process obeyed the Fick's law in the range of 0-100 microg x mL(-1).
CONCLUSIONThe absorption breviscapine photosomes is enhanced by increasing the permeability through a passive mechanism.
