Studies on anti-hyperglycemic effect and its mechanism of Dendrobium candidum.
- Author:
Hao-shu WU
1
;
Jian-hua XU
;
Li-zuan CHEN
;
Ji-jun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; metabolism; Dendrobium; chemistry; Diabetes Mellitus, Experimental; blood; pathology; Drugs, Chinese Herbal; isolation & purification; pharmacology; Epinephrine; Female; Glucagon; blood; Glycogen; metabolism; Hypoglycemia; chemically induced; metabolism; Hypoglycemic Agents; isolation & purification; pharmacology; Insulin; blood; Islets of Langerhans; drug effects; Liver; metabolism; Male; Mice; Plants, Medicinal; chemistry; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2004;29(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-hyperglycemic effect and its mechanism of Dendrobium candidum (DC).
METHODNormal mice, adrenaline-induced hyperglycemic mice, streptozotocin-induced diabetic (STZ-DM) rats were used. The mechanisms of the anti-hyperglycemic action were studied with radio-immunoassay, immunohistochemical HRP-SPA stain, etc.
RESULTDC could not obviously decrease the serum glucose concentrations and insulin levels in normal mice. It could increase serum insulin levels and decrease serum glucagons concentrations in STZ-DM rats. The results of immunohistochemical stain demonstrated that the number of islet beta cells was increased and that of islet a cells was decreased in STZ-DM rats. It could also decrease the serum glucose concentrations and increase liver glucogen contents in adrenaline-induced hyperglycemic mice.
CONCLUSIONDC has obvious anti-hyperglycemic effects in adrenaline-induced hyperglycemic mice and STZ-DM rats. Its mechanisms are stimulating the secretion of insulin from beta cells and inhibiting the secretion of glucagons from a cells, and it can probably decrease the decomposition of liver glucogen and increase the synthesis of liver glucogen.
