Clone of M2 autoantigens from human sources and evaluation of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis.
- Author:
Xiaohua JIANG
1
;
Renqian ZHONG
;
Xiaoqing TU
;
Wenwen LI
;
Xiantao KONG
Author Information
- Publication Type:Journal Article
- MeSH: Autoantibodies; immunology; Autoantigens; immunology; Chemical and Drug Induced Liver Injury; Enzyme-Linked Immunosorbent Assay; Hepatitis, Autoimmune; Humans; Liver Cirrhosis, Biliary; diagnosis; Sensitivity and Specificity
- From: Chinese Journal of Hepatology 2002;10(5):341-343
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the value of measurement of M2 autoantibodies in diagnosis of primary biliary cirrhosis (PBS).
METHODSM2 autoantibodies were detected by ELISA combined with western-blot.
RESULTSThirty-two cases presented positive M2 autoantibodies, including 20 cases of PBC, 9 liver diseases of unknown etiology, 1 autoimmune hepatitis and 1 drug-induced liver injury.
CONCLUSIONSM2 autoantibodies show good sensitivity and specificity to diagnosis of PBC. It should be used as a powerful and specific maker for the diagnosis of PBC
