Relationship between the genotypes of hepatitis B virus and the severity of liver diseases.
- Author:
Jun XU
1
;
Qi Xin WANG
;
Dong JIANG
;
Liu Ming YANG
;
Yan Long ZHAO
;
Hong Song CHEN
;
Lai WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Genotype; Hepatitis B virus; genetics; Hepatitis B, Chronic; virology; Humans; Male; Middle Aged; Sex Factors
- From: Chinese Journal of Hepatology 2003;11(1):11-13
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between different genotypes of hepatitis B virus (HBV) and the severity of liver diseases.
METHODSThe S nucleotide sequences of HBV strains isolated from plasma samples of 284 patients were detected and compared. Among them, 87 patients were HBV asymptomatic carriers (ASC), 157 chronic hepatitis B (CHB), 22 liver cirrhosis (LC), and 18 hepatocellular carcinoma (HCC).
RESULTSGenotypes B and C were predominant, with a 26.1% proportion and a 63.2% proportion respectively. The percentage of genotypes B and C in patients with ASC, CHB, LC, and HCC were significantly different (x(2)=15.09, P<0.001). Compared with genotype B, genotype C was more common in patients with CHB and HCC (59.6% vs 43.2%, chi(2)=10.87, P<0.001; 7.7% vs 1.4%, x(2)=7.41, P<0.001), but in patients with LC there was no different (7.7% vs 8.1%, chi(2)=1.29, P>0.05).
CONCLUSIONThis study suggests that genotype B and C are predominant. And genotype C may induce more severe the liver inflammation than genotype B may do.
