Production of Chemokines in Kawasaki Disease, Henoch-Schonlein Purpura and Acute Febrile Illness.
10.3346/jkms.2004.19.6.800
- Author:
Hyo Seok CHUNG
1
;
Hyo Young KIM
;
Hee Sun KIM
;
Hee Jung LEE
;
Ji Hyun YUH
;
Eun Sil LEE
;
Kwang Hae CHOI
;
Young Hwan LEE
Author Information
1. Department of Pediatrics, Yeungnam University, College of Medicine, Daegu, Korea. yhlee@med.yu.ac.kr
- Publication Type:Original Article ; Clinical Trial ; Comparative Study ; Controlled Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Mucocutaneous Lymph Node Syndrome;
Kawasaki Disease;
Purpura, Schonlein-Henoch;
Acute Febrile Illness;
Measles;
Gastroenteritis;
Pneumonia;
Tonsillitis;
Mumps;
Exanthem Subitum;
Chemokines, CC;
Chemokines, CXC;
Chemokines
- MeSH:
Acute Disease;
Adolescent;
Chemokines/*blood;
Child;
Child, Preschool;
Comparative Study;
Female;
Fever/*blood/*epidemiology;
Humans;
Infant, Newborn;
Korea/epidemiology;
Male;
Mucocutaneous Lymph Node Syndrome/*blood/*epidemiology;
Purpura, Schoenlein-Henoch/*blood/*epidemiology;
Research Support, Non-U.S. Gov't;
Risk Assessment/methods;
Risk Factors
- From:Journal of Korean Medical Science
2004;19(6):800-804
- CountryRepublic of Korea
- Language:English
-
Abstract:
We compared the production of three chemokines; interferon-gamma-inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) and growth-related onco-gene-alpha(Gro-alpha) that attracts monocytes or neutrophils, or both, in peripheral blood at acute stage of Kawasaki disease (n=29), Henoch-Schonlein purpura (n=15) and acute febrile illnesses (n=12). The production of the chemokines was assayed by ELISA. The plasma levels of IP-10 were markedly elevated in Kawasaki disease (538.6 +/-336.4 pg/mL) and acute febrile illnesses (417.1 +/-262.2 pg/mL) compared with in Henoch-Schonlein purpura (58.7 +/-95.7 pg/mL) (p<0.05). The MCP-1 levels were elevated in Kawasaki disease (443.0 +/-473.1 pg/mL) and acute febrile illnesses (328.6 +/-261.1 pg/mL) compared with in Henoch-Schonlein purpura (82.9 +/-79.0 pg/mL) (p<0.05). The Gro- levels were elevated only in acute febrile illnesses (134.3 +/-153.6 pg/mL) compared with in Kawasaki disease (31.8 +/-22.1 pg/mL) or Henoch-Schonlein purpura (29.4 +/-53.3 pg/mL) (p<0.05). According to these results, monocytes may play an important role in Kawasaki disease. In acute febrile illness-es, both monocytes and neutrophils may play an important role. By contrast, Henoch-Schonlein purpura may not be associated with the role of monocytes and neutrophils. Further studies using a larger number of cases are needed.
