Alpha-Adducin Gly460Trp Polymorphism and Essential Hypertension in Korea.
10.3346/jkms.2004.19.6.812
- Author:
Min Ho SHIN
1
;
Eun Kyung CHUNG
;
Hee Nam KIM
;
Kyeong Soo PARK
;
Hae Sung NAM
;
Sun Seog KWEON
;
Jin Su CHOI
Author Information
1. Department of Preventive Medicine, College of Medicine, Seonam University, Gwangju, Korea.
- Publication Type:Original Article ; Clinical Trial ; Controlled Clinical Trial ; Research Support, Non-U.S. Gov't
- Keywords:
Hypertension;
Adducin;
Polymorphism, Single Nucleotide
- MeSH:
Calmodulin-Binding Proteins/*genetics;
DNA Mutational Analysis/methods;
Female;
Genetic Predisposition to Disease/*epidemiology;
Genetic Screening/methods;
Humans;
Hypertension/*epidemiology/genetics/*metabolism;
Korea/epidemiology;
Male;
Middle Aged;
Mutation;
Polymorphism, Genetic/genetics;
Polymorphism, Single Nucleotide/*genetics;
Research Support, Non-U.S. Gov't;
Risk Assessment/*methods;
Risk Factors
- From:Journal of Korean Medical Science
2004;19(6):812-814
- CountryRepublic of Korea
- Language:English
-
Abstract:
Previous studies have suggested that the Gly460Trp polymorphism of the alpha-adducin gene (ADD-1) is associated with salt sensitivity and primary hypertension. The results of linkage or association studies of ADD-1 of different populations are controversial. This study investigated the relationship between the Gly460Trp poly-morphism of ADD-1 and essential hypertension in a Korean population. The subjects (n=903) were participants in a population-based study in Jangseong County, Korea. The Gly460Trp polymorphism of ADD-1 was determined using a polymerase chain reaction method. The frequency of the 460Trp allele was 59.4% in normotensives and 61.1% in hypertensives (p=0.523). The frequencies of the genotypes did not differ significantly between the hypertensive and normotensive groups (16.3% Gly/Gly, 45.8% Gly/Trp, and 38.0% Trp/Trp in normotensives; 16.2% Gly/Gly, 45.8% Gly/Trp, and 38.0% Trp/Trp in hypertensives; p=0.928). After adjusting for other risk factors, Gly/Trp and Trp/Trp were not associated with hypertension (OR 1.00, 95% CI 0.65-1.53, Gly/Trp vs. Gly/Gly; OR 1.22, 95% CI 0.79-1.90, Trp/Trp vs. Gly/Gly). These findings suggest that the Gly460Trp polymorphism of ADD-1 is not associated with hypertension.
