Thoughts and exploration on pharmacokinetic study of herbal medicines based on metabonomics and complex network.
- Author:
Zheng XIANG
1
;
Xiao-Jun CAI
;
Su ZENG
Author Information
1. School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou 325035, China. XZH007@126.com
- Publication Type:Journal Article
- MeSH:
Drugs, Chinese Herbal;
isolation & purification;
pharmacokinetics;
Humans;
Medicine, Chinese Traditional;
Metabolic Networks and Pathways;
Metabolomics;
Plants, Medicinal;
chemistry
- From:
Acta Pharmaceutica Sinica
2012;47(5):558-564
- CountryChina
- Language:Chinese
-
Abstract:
The change of drug development pattern pushes the innovation of drug valuation methods. The pharmacokinetic research of traditional Chinese medicines (TCM) is an important part of TCM modernization and plays a key role in novel drug development of TCM. However, the research methods and techniques are in consistent with the specific characteristics of TCM, i.e., multiple-components is still in the infant. This review makes a brief summary of current pharmacokinetic exploration of TCM, metabonomics and complex network, and puts forward a new strategy based on complex network and metabonomics to study TCM pharmacokinetic in order to disclose the active components and mechanism of TCM.
