A novel C27-steroidal glycoside sulfate from Liriope graminifolia.
- Author:
Kui-Wu WANG
1
;
Xian-Yan JU
;
Lei ZHANG
;
Wei WANG
;
Lian-Qing SHEN
Author Information
1. School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, China. wkw220@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Cell Proliferation;
drug effects;
Drugs, Chinese Herbal;
chemistry;
isolation & purification;
pharmacology;
Glycosides;
chemistry;
isolation & purification;
pharmacology;
HL-60 Cells;
Hesperidin;
chemistry;
isolation & purification;
pharmacology;
Humans;
Inhibitory Concentration 50;
K562 Cells;
Liriope Plant;
chemistry;
Plant Tubers;
chemistry;
Plants, Medicinal;
chemistry;
Spirostans;
chemistry;
isolation & purification;
pharmacology
- From:
Acta Pharmaceutica Sinica
2012;47(5):619-623
- CountryChina
- Language:Chinese
-
Abstract:
An unusual novel C27-steroidal glycoside sulfate was isolated from the underground organs of Liriope graminifolia (Linn.) Baker with three known compounds. Their chemical structures were determined by spectral analysis, including HR-MS, 1D and 2D NMR as (25S)-ruscogenin 1-sulfate-3-O-alpha-L-rhamnopyranoside (1), (25S)-ruscogenin 1-O-beta-D-xylopyranosyl-3-O-alpha-L-rhamnopyranoside (2), hesperidin (3), and 4', 7-dihydroxy-5-methoxyflavanone (4). Compound 1 has cytotoxic activities against K562 and HL60 cells with IC50 values of 18.6 microg x mL(-1) and 16.5 microg x mL(-1), respectively.
