Advance in the study of targeting delivery system for siRNA mediated by aptamers.
- Author:
Xiao-Lin WANG
1
;
Qing-Qing WANG
;
Hai-Feng SONG
Author Information
1. Guangxi Medical University, Nanning 530002, China.
- Publication Type:Journal Article
- MeSH:
Aptamers, Nucleotide;
administration & dosage;
metabolism;
Drug Delivery Systems;
methods;
Humans;
Neoplasms;
therapy;
RNA Interference;
RNA, Small Interfering;
administration & dosage;
metabolism;
SELEX Aptamer Technique
- From:
Acta Pharmaceutica Sinica
2012;47(7):850-855
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference (RNAi), as a new technology of gene therapy, has been used in the studies of many diseases in vitro, however, targeting delivery of small interference RNA (siRNA) is still a bottleneck for clinical therapy of siRNA agents. Aptamer is a group of oligonucleotides with high affinity and targeting, and is becoming another important means of delivery for siRNA. In this review, we summarized siRNA delivery obstacles in vivo and recent attractive developments increatively using cell-internalizing aptamers to deliver siRNAs to target cells.
