Immunoregulatory effect of artesunate on allergic contact dermatitis and its mechanism.
- Author:
Tan LI
1
;
Hong CHEN
;
Xiao-Guang LIU
;
Ya-Xun ZHOU
;
Shu-Fang BAI
Author Information
1. Department of Immunology, Logistics University of the Chinese People's Armed Police Force, Tianjin 300162, China.
- Publication Type:Journal Article
- MeSH:
Administration, Topical;
Animals;
Artemisinins;
administration & dosage;
chemistry;
pharmacology;
Dermatitis, Allergic Contact;
immunology;
metabolism;
pathology;
Ear;
pathology;
Female;
GATA3 Transcription Factor;
genetics;
metabolism;
Hypersensitivity, Delayed;
drug therapy;
Immunosuppressive Agents;
administration & dosage;
chemistry;
pharmacology;
Interferon-gamma;
genetics;
metabolism;
Interleukin-4;
genetics;
metabolism;
Mice;
Mice, Inbred ICR;
Molecular Structure;
NF-kappa B;
metabolism;
RNA, Messenger;
metabolism;
T-Box Domain Proteins;
genetics;
metabolism
- From:
Acta Pharmaceutica Sinica
2012;47(7):884-889
- CountryChina
- Language:Chinese
-
Abstract:
This study is to elucidate the immunoregulation mechanisms of artesunate (AST) on allergic contact dermatitis (ACD). Pharmacodynamics analyses, HE staining, semi-quantitative RT-PCR and Western blotting were used to explore the effects of AST on the related cytokines, transcription factor and signaling molecule of ACD respectively. The results indicated that topical administration of AST not only reduced the increase of ear swelling, spleen index and inflammatory cells infiltration in ACD mice, but also inhibited remarkably the expression of IFN-gamma, T-bet and NF-kappaB p65. It's suggested that AST could exhibit suppressive effects on inflammatory response and immune function of ACD, which indicates the possibility of developing AST as a novel immunoregulatory agent in the treatment of ACD and other immune-related diseases.
