Human HSF1 mutants and their applications.
- Author:
Yun-Hong HUANG
1
;
Shou-Fang GONG
;
Jiang-Ying ZOU
Author Information
1. Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China.
- Publication Type:Journal Article
- MeSH:
Genetic Therapy;
Heat-Shock Proteins;
genetics;
therapeutic use;
Humans;
Mutant Proteins;
genetics;
Neoplasms;
therapy;
Neurodegenerative Diseases;
therapy
- From:
Chinese Journal of Biotechnology
2007;23(6):971-975
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock factor 1 (HSF1) is the key protein in regulating stress response. It can be activated under heat, oxidative or another stress conditions. Dominant-positive and dominant-negative HSF1 are two types of HSF1 mutants. Both of them gain the DNA binding activity in the absence of stress. In addition, dominant-positive HSF1 acquires transcriptional activity, which dominant-negative HSF1 does not acquire. In this paper, the progress of using these HSF1 mutants in the research of cancer, neurodegenerative disorders and cardiovascular diseases will be discussed.