Antibacterial activity and property of the fermentation product of marine Streptomyces sp. GB-2.
- Author:
Shu LIU
1
;
Ying-Jian LU
;
Zhao-Xin LU
;
Feng-Xia LÜ
;
Xiao-Mei BIE
;
Yao-Wei FANG
;
Zhong-Yang DING
Author Information
1. College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
- Publication Type:Journal Article
- MeSH:
Anti-Bacterial Agents;
biosynthesis;
isolation & purification;
pharmacology;
Escherichia coli;
drug effects;
Fermentation;
Microbial Sensitivity Tests;
Seawater;
microbiology;
Staphylococcus aureus;
drug effects;
Streptomyces;
chemistry
- From:
Chinese Journal of Biotechnology
2007;23(6):1077-1081
- CountryChina
- Language:Chinese
-
Abstract:
Marine Streptomyces GB-2, isolated from marine samples collected in the intel tidal zone of Lianyungang, was found to produce antibacterial substance which exhibited significant inhibitory effects on 11 Gram-positive bacteria and 4 Gram-negative bacteria. The antibacterial substance was proved to be neutral and water-soluble according to paper chromatogram analysis, and its production was significantly associated with aritificial seawater. The stability analysis of the fermentation broth of Streptomyces GB-2 showed that it was very stable at pH1 and pH12 under 121 degrees C and changed very little under ultraviolet treatment. The substance produced by strain GB-2 exhibited potential use in the areas of bio-control, food and medical application.
