Correlation of FOXA1 with the malignancy and progression of prostate cancer.
- Author:
Wei FENG
;
Hong-bin ZHANG
;
Yang-min WANG
;
Ju-long HU
- Publication Type:Journal Article
- MeSH: Disease Progression; Hepatocyte Nuclear Factor 3-alpha; metabolism; Humans; Ki-67 Antigen; metabolism; Male; Neoplasm Grading; Neoplasm Proteins; metabolism; Prostatic Hyperplasia; metabolism; pathology; Prostatic Neoplasms; metabolism; pathology
- From: National Journal of Andrology 2015;21(5):414-419
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship of the expression of FOXA1 in the prostate cancer (PCa) tissue with the Gleason score and clinical staging of PCa and with castration-resistant PCa (CRPC).
METHODSUsing the immunohistochemical method, we detected the expressions of FOXA1 and Ki-67 in the pathological sections of 35 cases of PCa and 21 cases of benign prostatic hyperplasia (BPH). Then we analyzed their correlation with the Gleason score and TNM staging of PCa and that with CRPC.
RESULTSThe positive expression of FOXA1 was significantly higher in the PCa than in the BPH tissue (P < 0.001) and was positively correlated with that of Ki-67 (P < 0.001) as well as with the Gleason score (P = 0.027) and clinical staging of PCa (P = 0.002), but showed no correlation with CRPC (P = 0.391).
CONCLUSIONThe positive expression of FOXA1 is increased in PCa, most significantly in the advanced stage of the tumor.