Transrectal shear wave elastography combined with transition zone biopsy for detecting prostate cancer.
- Author:
Mo ZHANG
;
Peng WANG
;
Bo YIN
;
Xiang FEI
;
Xue-wen XU
;
Yong-sheng SONG
- Publication Type:Journal Article
- MeSH: Elasticity Imaging Techniques; methods; Humans; Image-Guided Biopsy; methods; Male; Prostate; pathology; Prostatic Neoplasms; diagnosis; diagnostic imaging; pathology; ROC Curve; Sensitivity and Specificity
- From: National Journal of Andrology 2015;21(7):610-614
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the application of shear wave elastography (SWE) combined with transition zone biopsy in the detection of prostate cancer (PCa).
METHODSA total of 489 patients with suspected PCa underwent transrectal ultrasonography (TRUS) and SWE-guided prostatic biopsy. We evaluated the role of SWE combined with transition zone biopsy in promoting the detection rate in comparison with the results of biopsy pathology.
RESULTSThe pathological results confirmed 221 malignant and 268 benign cases. Based on systematic biopsy, SWE combined with transition zone biopsy achieved a detection rate of 45. 19% , significantly higher than that of systematic biopsy alone (33.13%) (P < 0.05). The diagnostic sensitivity, specificity, and accuracy of SWE were significantly better than those of TRUS (P < 0.05). The mean elasticity (Emean) of SWE was remarkably higher for malignant than for benign lesions ([40.1 ± 9.5] vs [21.6 ± 8.3] kPa, P < 0.05). With 28.5 kPa as the threshold of the Emean value, the area under the ROC curve was 0. 899, and the diagnostic sensitivity and specificity were 88.71% and 86.23%, respectively.
CONCLUSIONSWE combined with transition zone biopsy could significantly improve the detection rate of prostate cancer.