Prostatic inflammation-induced chronic pelvic pain: Roles of substance P and c-fos in the spinal cord.
- Author:
Ying-jia LIU
;
Guo-hong SONG
;
Chen ZHANG
- Publication Type:Journal Article
- MeSH: Animals; Chronic Disease; Immunohistochemistry; Male; Pelvic Pain; etiology; metabolism; Prostate; metabolism; Prostatitis; complications; metabolism; Proto-Oncogene Proteins c-fos; metabolism; Rats; Rats, Wistar; Spinal Cord; metabolism; Substance P; metabolism; Syndrome; Up-Regulation
- From: National Journal of Andrology 2015;21(8):681-686
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possible pain mechanism of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).
METHODSThe models of CP/CPPS were established in male Wistar rats by the autoimmune method. The paw withdrawal threshold (PWT) was detected using Von Frey filament. The expressions of the substance P and c-fos in the prostate and spinal L5-S2 segments were determined by immunohistochemistry followed by analysis of their correlation with CP/CPPS.
RESULTSCompared with the control rats, the CP/CPPS models showed significantly decreased PWT (P < 0.05), remarkable prostatic inflammation, enlarged scope of lesions, and obvious interstitial lymphocytic infiltration (P < 0.05). Both the expressions of substance P and c-fos were markedly elevated in the prostate and spinal dorsal horn (L5-S2) of the rat models (P < 0.05), but the expression of substance P in the prostate exhibited no correlation with that in the spinal cord (r = 0.099, P = 0.338), nor did that of c-fos (r = 0.027, P = 0.454).
CONCLUSIONThe upregulated expressions of substance P and c-fos in the spinal cord L5-S2 sections may be associated with the pain mechanism of CP/CPPS.