Induced differentiation of stem cells into androgen-secreting cells.
- Author:
Zhi-yuan ZHANG
;
Jie SUN
- Publication Type:Journal Article
- MeSH:
Androgens;
secretion;
Cell Differentiation;
physiology;
Humans;
Hypogonadism;
therapy;
Hypothalamus;
physiology;
Male;
Pituitary Gland;
physiology;
Stem Cells;
cytology;
secretion
- From:
National Journal of Andrology
2015;21(8):753-756
- CountryChina
- Language:Chinese
-
Abstract:
Leydig cells are the major source of androgens in males. Stem cells can be induced to differentiate into androgen-secreting Leydig like cells, whose functions are regulated by the hypothalamus and pituitary, so that they precisely secret the necessary hormones to maintain physiological function. Therefore, the establishment of an effective protocol to induce the differentiation of stem cells into androgen-secreting cells is very helpful for the treatment of hypogonadism caused by abnormalities of Leydig cells. This review outlines the recent findings concerning the differentiation of stem cells into androgen-secreting cells.
