Efficacy and tolerability of dapoxetine in the treatment of premature ejaculation.
- Author:
Lin YANG
;
Lei LUO
;
Xing-fa CHEN
;
Jin-hai FAN
;
Run-ming LIU
;
Xiao-ning WANG
;
Xun-yi NAN
;
Yue ZHANG
;
Xiao-feng LIN
;
Ming-zhu WANG
;
Jun-ping XING
;
Zhi-shang YANG
;
Bai-lu JIAN
;
Hui HE
;
Da-peng WU
;
Da-lin HE
- Publication Type:Journal Article
- MeSH: Benzylamines; adverse effects; therapeutic use; Double-Blind Method; Ejaculation; drug effects; physiology; Humans; Male; Naphthalenes; adverse effects; therapeutic use; Outpatients; Premature Ejaculation; drug therapy; Reaction Time; drug effects; physiology; Serotonin Uptake Inhibitors; adverse effects; therapeutic use; Sertraline; administration & dosage; adverse effects; Time Factors; Treatment Outcome
- From: National Journal of Andrology 2015;21(10):892-895
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy and adverse effects of dapoxetine in the treatment of premature ejaculation.
METHODSWe randomly assigned outpatients with premature ejaculation in the proportion of 2:1 to receive 30 mg dapoxetine on demand (n =78) or 50 mg sertraline qd for one month (n = 39). Follow-up was accomplished in 95 cases, 63 in the dapoxetine group and 32 in the sertraline group. We recorded the intravaginal ejaculatory latency time (IELT), clinical global impression of change (CGIC) score, and adverse reactions of the patients and compared them between the two groups.
RESULTSIELT was significantly increased in both the dapoxetine (from [0.87 ± 0.31] to [2.84 ± 0.68] min, P < 0.05) and the sertraline group (from [0.84 ± 0.28] to [2.71 ± 0.92] min, P < 0.05) after medication. Based on the CGIC scores in premature ejaculation, the rate of excellence or effectiveness was 36.5% in the dapoxetine and 37. 5% in the sertraline group, and the rate of improvement was 63.5% in the former and 71.9% in the latter. The incidence rates of dizziness, nausea, headache, and diarrhea were slightly higher (P > 0.05) while those of fatigue, somnolence, and dry mouth significantly higher (P < 0.05) in the sertraline than in the dapoxetine group.
CONCLUSIONOn-demand oral medication of dapoxetine is effective and well-tolerated for the treatment of premature ejaculation.