Induced pluripotent stem cells in spermatogenesis: Progress in current studies.
- Author:
Fang FANG
;
Ke NI
;
Cheng-liang XIONG
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Differentiation;
Germ Cells;
Humans;
Induced Pluripotent Stem Cells;
Infertility, Male;
therapy;
Male;
Mice;
Spermatogenesis
- From:
National Journal of Andrology
2015;21(10):925-930
- CountryChina
- Language:Chinese
-
Abstract:
Spermatogenesis is a complex process. Current knowledge about human spermatogenesis is mainly based on the mouse model while little is known about the initial stage of this fundamental process in humans. The establishment of the model of spermatogenesis in vitro may contribute to an overall understanding of male germ cell development, an insight into the mechanisms of infertility, and clinical management of male infertility. This review summarizes current knowledge about the generation of germ cell-like cells from induced pluripotent stem cells (iPSCs) in vitro and discusses the potential application of iPSCs in the treatment of male infertility.
