Relationship between epithelial-mesenchymal transition and lung metastasis in hepatocellular carcinoma.
- Author:
Yan WANG
1
;
Tong-chun XUE
;
Xiao-ying XIE
;
Yi CHEN
;
Sheng-long YE
;
Zheng-gang REN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Cadherins; metabolism; Carcinoma, Hepatocellular; metabolism; pathology; Cell Differentiation; Epithelial Cells; pathology; Female; Fibronectins; metabolism; Follow-Up Studies; Humans; Liver Neoplasms; metabolism; pathology; Lung Neoplasms; secondary; Male; Middle Aged; Neoplasm Metastasis; Stromal Cells; pathology; Vimentin; metabolism
- From: Chinese Journal of Surgery 2008;46(21):1624-1627
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the relationship between epithelial mesenchymal transition (EMT) and lung metastasis in hepatocellular carcinoma.
METHODSThere were 100 patients who underwent surgical resection of hepatocellular carcinoma between January 2000 and March 2004. They were classified with non-distance metastasis and lung metastasis depend on the close following up till March 2007. Their hepatocellular carcinoma specimens were retrospectively examined for EMT markers (E-cadherin, Vimentin, Fibronectin) with immunochemistry staining in tissue microarray. Univariate and multivariate analysis were used for study the relationship between EMT and lung metastasis.
RESULTSUnivariate analysis showed that down regulation of E-cadherin, overexpression of fibronectin, cytosolic expression of vimentin, AFP >or= 400 ng/ml, tumor size more than 10 cm, portal vein involvement, poorly differentiated of tumor had close correlation with lung metastasis. Multivariate analysis indicated that overexpression of fibronectin was independent factor for lung metastasis apart from tumor size more than 10 cm, portal vein involvement and poorly differentiated of tumor.
CONCLUSIONThe results proposed that EMT has close relation with lung metastasis in hepatocellular carcinoma.
