Reversible Cerebellar Leukoencephalopathy Associated With Oral Methotrexate.
- Author:
Juyoun LEE
1
;
Eungseok OH
;
Seong Hae JEONG
;
Eun Hee SOHN
;
Ae Young LEE
Author Information
1. Department of Neurology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. aelee@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Leukoencephalopathy;
Methotrexate;
Cerebellum
- MeSH:
Administration, Intravenous;
Aged;
Cerebellum;
Female;
Humans;
Leukoencephalopathies*;
Methotrexate*;
Walking
- From:Journal of the Korean Neurological Association
2014;32(3):168-170
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Methotrexate (MTX)-induced leukoencephalopathy is the most often reported leukoencephalopathy following intrathecal or intravenous administration. A 72-year-old woman developed leukoencephalopathy localized to the cerebellum after treatment with oral MTX at a dose of 15 mg/week for 3 years. She complained of subtle imbalance during walking and reported having fallen. Her symptoms improved after discontinuation of MTX, and the leukoencephalopathy resolved. This is therefore a case report of selective cerebellar reversible leukoencephalopathy associated with oral MTX.
