Effect of toluene diisocyanate on lung function of workers.

Bao-feng Liu; Hui Liu; Ming Zhang; Xin Zhao; De-yi Yang; Jie Ren; Yan-rang Wang

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Effect of toluene diisocyanate on lung function of workers.

Author: Bao-feng LIU ¹ ; Hui LIU ¹ ; Ming ZHANG ¹ ; Xin ZHAO ¹ ; De-yi YANG ¹ ; Jie REN ¹ ; Yan-rang WANG ²
Author Information

1. Institute of Occupational Disease Control and Prevention, Tianjin Centers for Disease Control and Prevention Tianjin 300011, China.
2. Institute of Occupational Disease Control and Prevention, Tianjin Centers for Disease Control and Prevention Tianjin 300011, China. E-mail: tjcdczhy@126.com.
Publication Type:Journal Article
MeSH: Case-Control Studies; Forced Expiratory Volume; Humans; Lung; drug effects; physiopathology; Male; Occupational Exposure; Toluene 2,4-Diisocyanate; adverse effects; Vital Capacity; drug effects
From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2013;31(11):844-845
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the effect of long-term exposure to toluene diisocyanate (TDI) on the lung function of TDI-exposed workers.
METHODSA factory was selected for this occupational epidemiological investigation. The workers who were exposed to TDI and had complete physical examination records in recent 3 years were the exposed group (n = 45), while the company's administrative staff, logistics staff, and other non-TDI-exposed workers who had complete physical examination records in recent 3 years were the control group (n = 47). The two groups were compared in terms of lung function indices.
RESULTSCompared with the control group, the 2009 exposure group had significantly lower forced expiratory volume in one second (FEV1.0), FEV1.0/forced vital capacity (FVC), and maximal expiratory flow at 25% of FVC (MEF25) (P < 0.05), the 2010 exposure group had significantly lower FEV1.0, FEV1.0/FVC,maximum voluntary ventilation (MVV), and maximal expiratory flow at 50% of FVC (MEF50) (P < 0.05), and the 2011 exposure group had significantly lower FEV1.0, FEV1.0/FVC, peak expiratory flow (PEF), MEF25, and MEF50 (P < 0.05).
CONCLUSIONLong-term exposure to TDI can lead to certain impairment of lung function in workers, which may be reflected by decreased lung function indices such as vital capacity, FVC, FEV1.0, FEV1.0/FVC, PEF, and MVV.