Alterations of SP-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluid in children with Mycoplasma pneumoniae pneumonia.
- Author:
Lin-hua SHU
1
;
Yun-xiao SHANG
;
Xu-xu CAI
;
Zhi-hong ZONG
;
Xiao-na MENG
;
Han ZHANG
;
Zhi-jia WANG
;
Bing DAI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Biomarkers; blood; metabolism; Bronchoalveolar Lavage Fluid; chemistry; Child; Child, Preschool; Female; Humans; Infant; Lung; metabolism; pathology; Male; Mucin-1; blood; metabolism; Pneumonia, Mycoplasma; blood; metabolism; Pulmonary Surfactant-Associated Protein A; blood; metabolism; Pulmonary Surfactant-Associated Protein D; blood; metabolism; Severity of Illness Index
- From: Chinese Journal of Pediatrics 2013;51(10):779-782
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the alterations and relationship of surfactant protein (SP)-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluids (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP).
METHODSelf-control method was used for the study on SP-A, SP-D and KL-6 in serum, infected and non-infected BALFs in 32 MMP children with only one side of MPP.
RESULTThe contents of SP-A, SP-D and KL-6 in infected BALF were [mg/L;M (IQR) ]: 243 (90-468) , 187 (43-333) , 148 (47-426) ;104 (37-257) , 56 (25-131) , 35 (12-147) in non-infected BALF; 35 (25-69) , 33 (9-149) and 24 (15-62) in serum. The correlation coefficient of KL-6 between serum and infected BALF were -0.534 and -0.378 (P < 0.05).
CONCLUSIONThere were significant correlation between the alterations of SP-A, SP-D and KL-6 in serum and lung infection in children with CAP. KL-6 in serum may be more sensitive than SP-A and SP-D.
