Research progress on regulation effect of Panax notoginseng saponins on mitochondria.
10.19540/j.cnki.cjcmm.20170121.010
- Author:
Zi-Ping YANG
1
;
Yi-Min BAO
1
Author Information
1. College of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
Panax notoginseng saponins;
energy metabolism;
mitochondria;
mitochondrial ATP-sensitive K⁺ channels;
mitochondrial membrane permeability transition pore;
mitophagy;
oxidative stress
- From:
China Journal of Chinese Materia Medica
2017;42(5):870-874
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellular functions. As the most important active ingredients in Chinese medicine pseudo-ginseng, Panax notoginseng saponins(PNS) have pharmacological effects on protecting against thrombosis, dilating blood vessels, lowering the blood pressure, anti-inflammation, and antioxidant, etc. Domestic and foreign studies have shown that PNS participates in regulating mitochondrial energy metabolism, oxidative stress, biosynthesis, apoptosis, mitophagy and the status of membrane channels. Therefore, the mitochondria is one of the important targets of PNS. In this paper, the regulation effects of P. notoginseng saponins on mitochondria were reviewed.
