A new styrene dimer derivative from Litsea greenmaniana.

Author: Ya-Nan WANG ¹ ; Ling-Yan WANG ¹ ; Yu-Hong QU ¹ ; Ming JIANG ¹ ; Yu-Zhuo WU ¹ ; Rui LI ¹ ; Bo-Lin QIU ¹ ; Su-Juan WANG ¹ ; Sheng LIN ¹
Author Information

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Publication Type:Journal Article
Keywords: Litsea greenmaniana; chemical constituents; styrene dimer derivative
From: China Journal of Chinese Materia Medica 2017;42(5):912-914
CountryChina
Language:Chinese
Abstract: A new styrene dimer derivative has been isolated from the branch of Litsea greenmaniana by column chromatography over silica gel and Sephadex LH-20, as well as semi-preparative HPLC. Its structure was identified by spectroscopic data analysis (MS, UV, IR, 1D and 2D NMR) as (E)-2,4-bis(p-hydroxyphenyl)-2-butenol, named as listeanol. At a concentration of 1×10-5 mol•L⁻¹, compound 1 was inactive in the assays, including cytotoxicity against human tumor cell lines (HCT-8, Bel-7402, BGC-823, A549 and A2780), antioxidant activity in Fe²⁺-cystine-induced rat liver microsomal lipid peroxidation, neuroprotective activity against serum deprivation or glutamate induced neurotoxicity in cultures of PC12 cells, and the inhibitory activity against protein tyrosine phosphatase 1B (PTP1B).