Explore molecular mechanism of Chinese herbs with promoting blood circulation and resolving phlegm effects on myocardial ischemia reperfusion injury based on correlation between microRNA and mtDNA.
10.19540/j.cnki.cjcmm.20170121.022
- Author:
Fei LIN
1
;
Heng-Wen CHEN
2
;
Zhuo-Lin SHI
1
;
Guo-An ZHAO
1
;
Ye-Xi SUN
3
Author Information
1. The First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China.
2. Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
3. Renji College of Wenzhou Medical University, Wenzhou 325035, China.
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
lipid metabolism;
microRNA;
mitochondria
- From:
China Journal of Chinese Materia Medica
2017;42(5):1005-1010
- CountryChina
- Language:Chinese
-
Abstract:
A large number of basic and clinical studies have shown that the Chinese herbs with promoting blood circulation and resolving phlegm effects could prevent and treat myocardial ischemia-reperfusion injury(MIRI) by regulating lipid metabolism. But its mechanism is not yet clear. The studies show that mitochondrial DNA (mtDNA), microRNAs and lipid metabolism participate in the whole process of MIRI and affect the prognosis. mtDNA mutation is the primary factor to cause myocardial ischemia and reperfusion myocardial cell damage. microRNAs aggravate or reduce MIRI injury by down-regulating or up-regulating related genes expression, while miR-33, as a key regulator of cholesterol transport, regulates lipid metabolism through CROT, PGC-1α, AMPK and other genes located in the mitochondria. There are less studies on correlation between miR-33 and mtDNA, microRNAs. Therefore, further studies on the correlation between miR-33 and mtDNA, microRNAs, as well as the discussions on whether the traditional Chinese medicine (TCM) with promoting blood circulation and resolving phlegm effects could target miR-33 to regulate lipid metabolism and inducemt DNA mutations or deletions, would have important significance for the prevention and treatment of MIRI.
